Ofloxacin and Ornidazole tablets are known as a combination antibiotic drugs used to treat several bacterial and parasitic infections.
With medicines being easier to access due to a surge in illnesses everywhere, it is also important to know that not all medicines are the same. It is also important to focus on its therapeutic applications for conditions like bacterial infections, parasitic infections, and more.
In this blog, Know about the Ofloxacin and Ornidazole Tablets Uses, Side effects, Composition, dosage and more
Ofloxacin and Ornidazole: Overview
About Ofloxacin
Ofloxacin is a broad-spectrum type of antibiotic that belongs to the fluoroquinolone class, which is used to treat bacterial infections. It works quickly by inhibiting two essential enzymes, such as DNA gyrase and topoisomerase IV, which are critical for bacterial DNA replication, transcription, and repair. The inhibition brought by this antibiotic prevents bacterial cell division, thus leading to the ultimate death of susceptible bacteria. however, users and doctors must be aware that the antibiotic does carry some potential side effects, including nausea, diarrhea, headache, and dizziness.
About Ornidazole
Ornidazole is an antimicrobial drug that belongs to the nitroimidazole class and is used to treat infections caused by anerobic bacteria and protozoa. The drug works by penetrating the microbial cells, where the nitro group is reduced, thus forming toxic metabolites used to disrupt DNA synthesis and ultimately causing the death of cells.
It is commonly used to treat conditions like dysentery, giardiasis, bacterial vaginosis, pelvic inflammatory diseases, and even post-surgical infections. It is most commonly used in combination with antibiotics like Ofloxacin to treat severe infections like diarrhea, dysentery, and more.
Ofloxacin and Ornidazole Tablets Composition
The Oflaxin and Ornidazole tablets are known to combine two potent active ingredients to form a very effective drug that is primarily used to combat infections caused by bacteria and protozoa.
Ofloxacin (200 mg)
The Ofloxacin is an antibiotic belonging tot he fluroquinolone class that targets bacterial DNA gyrase and topoisomerase IV – these are rather critical enzymes that are involved in the bacterial DNA replication, transcription and even repair. Ofloxacin prevents bacterial cell dvision effectively eliminating the infection completely. This is particularly effective against gram-negative bacterium as well some gram-positive bacteria.
Ornidazole (500 mg)
The Ornidazole is a derivative of the nitromidazole class which includes both antibacterial and antiprotozoal properties. These help disrupt the DNA synthesis in anaerobic bacteria and protozoa by generating toxic metabolites, thus leading to the ultimate death of the cell. The ornidazole is highly effective against such infections like amoebiasis and giardiasis, and also anaerobic bacterial infections.
Ofloxacin and Ornidazole Tablets Uses
Ofloxacin and Ornidazole tablets are prescribed for a wide range of infections but here are some of the most commonly found uses of the tablets:
- Diarrhea and Dysentery: These drugs are highly effective in treating acute and chronic diarrhea inclouding dysentrry caused from bacterial diarrhea caused by pathogens like salmonella and shigella, and even E.coli. Such pathogens cause symptomos such as loose stools, abdominal cramps and dehydration.
- Gastrointestinal Infection: The combination is used to combat infections like giardiasis and amebiasis which end up causing situations like bloating, nausea and also abdominal pain. It is also effective against infections in the gastrointestinal tract.
- Urinary Tract Infections (UTI): The Ofloxacin and Ornidazole tablets are prescribed for UTI caused by E.Coli, proteus mirabilis and other such bacterias. They help relieve symptoms such as burning sensations during urination, increased frequency of urination and pelvic pain.
- Gynaecological Infections: The combination drug is effective in combatting bacterial vaginosis, pelvic inflammatory diseases and more that are caused by anaerobic bacteria. WIth this drug, you can help reduce the symptoms that are normally present such as vaginal discharge, itching and pelvic discomfort.
- Sexually Transmitted Infections (STI): In severe cases of STI like chlamydia or gonorrhea, this combination drug works hard to combat and prevent the recurrence of these diseases. It also prevents antibiotic resistance.
- Skin and Soft Tissue Infections: These tablets are effective in combating the ill-effects of conditions like cellulitis, abscesses and wound infections that are caused by anerobic bactreria.
Benefits
The benefits of the Ofloxacin and Ornidazole tablets are multi-faceted – that means they have several types of benefits that are offered to the patients and those who consume them. These benfits include:
- Powerful Dual Action: The combination drug is known to target a wide range of bacteria caused pathogens including gram-negative and positive bacteria, anaerobic bacteria and even protozoa.
- Quick Relief from Symptoms: Patinets who consume this drug typically end up feeling relief from their symptoms of diarrhea, abdominal pain, fever and urinary discomfort withn 1-3 hours of the first dose with more significant improvement within 24 hours.
- Simplified Treatmet Regime: Having combined two active ingredients in a singular tablet ensures that you don’t need a cocktail of multiple medications thus improving and even reducing the treatment regime to a bare minimum.
- Short Treatment Duration: In some cases like acute diarrhea, the treatment normally takes a lot of time and is a long-drawn out process but with this drug, it can be treated within a 3-5 day course.
- Cost-Effective: This is a bonus benefit – many combination drugs are not available and if they are, they aren’t exactly cheap but this drug is available everywhere at a very reasonable price of INR 54.
Side Effects
A lot of the time there are some common side effects that take place – this is quite common and thus, the known and common side effects of this drug include:
- Gastrointestinal effects such as nausea, vomiting, diarrhea, abdominal pain, loss of appetite and flatulence are quite common.
- Neurological side effects like headache, dizziness, sleep disturbance, insomnia and fatigue.
- Dermatological side effects like rashes, itching, and more.
Some serious side effects include:
- Tendon Damage: This drug may in some severe cases, cause tendon rupture particularly in the Achilles tendon. The symptoms include pain, swelling or stiffness in the tendons. Should these symptoms occur, contact your doctor immediately and discontinue.
- Allergic Reactions: Severe allergic reactions are quite rare but it may include rashes, itching and even difficulty in breathing. Contact your doctor immediately.
- Neurological Effects: This is a rare case scenario but symptoms like seizures, confusion, hallucinations, tremors or conditions like tingling, numbness and burning have been reported. This is of course an abnormal case situation.
- Cardiac Effects: This drug even cause issues like irregular heart beats, and this is more likely for those patients who have pre-existing heart conditions.
Dosage
The dosage of the Ofloxacin and Ornidazole tablets depend on the type and severity of the infection but also on the age, weight and overall health of the patient.
For Adults
The standard dose is confined to one tablet which should be taken orally twice a day, or every 12 hours for a minimum of 5 days and a maximum of 10 days depending on the type of infection. The tablet must be swallowed with a glass of water – with or without food.
For Children below 8 years
For such patients, a suspension form is available for paediatric usage. This means that the Ofloxacin is available for 50 mg, and Ornidazole is available for 125 mg per 5 ml. The typical dose is 2-2.5 ml twice a day and it depends on the child’s body weight. However you must know that this medicine is not recommended to children under the age of 18 years unless your paediatrician prescribes it.
Elderly Patients
For such patients, there might be adjustments made for the dosage. This is especially true for those patients who have a reduced kidney or faulty liver function.
It is important to note that in case you miss a dose, you must take your next dose as soon as possible. Don’t double up the dosage to make up for the missed one as this causes overdose.
Ofloxacin and Ornidazole Tablets Price
The price of the Ofloxacin and Ornidaxole tablets vary depending on the brand, location and the pharmacy. In India, a strip of 10 tablets ranges anywhere between INR 45 and INR 200. Some of the popular brands include:
- Ornidox (10 tabs) costs INR 80.78 after discount of 12%
- Oflox OZ (10 tabs) costs INR 152-200
- Oflotas OZ (10 tabs) costs INR 82.15
- Zanocin OZ (10 tabs) costs INR 100-150.
Disclaimer
In the Below, Given Information about the Ofloxacin and Ornidazole tablets, only for knowledge, don’t take this medicine without doctor advice.
Refresh Date: August 22, 2025
